Diagnosing Alzheimer's: Clinical Criteria and Diagnostic Tools

Diagnosing Alzheimer’s: Clinical Criteria and Diagnostic Tools

PA Mast explains the step-by-step diagnostic process, including cognitive and functional assessments, MRI and PET imaging, and cerebrospinal fluid and blood-based biomarkers. He emphasizes that no test should be used in isolation and offers insights into how his practice sequences evaluations over multiple visits. He also touches on the value of patient-friendly communication and ensuring patients don’t feel overwhelmed.

Key Takeaways:

Diagnosis begins with a complete medical history and exam, including cognitive, functional, and behavioral tests.
Other tests such as imaging and genetic testing can provide further insights; blood biomarkers are a promising tool for earlier diagnosis.
The diagnosis process can be overwhelming for patients; pace tests as needed.

Previous Video Next Video

Speaker

Click on the photo below to learn more about the speaker.

Jordan Mast, MMS, PA-C

References and Additional Resources:

Alzheimer’s association statement on first blood test used in diagnosing Alzheimer’s disease cleared for use by FDA. Alzheimer’s Association. May 16, 2025. Accessed July 23, 2025. https://www.alz.org/news/2025/fda-clears-blood-test-alzheimers-diagnosis

Medical Tests for Diagnosing Alzheimer’s. Alzheimer’s Association. Accessed July 23, 2025. https://www.alz.org/alzheimers-dementia/diagnosis/medical_tests

Supported by

Jordan Mast, MMS, PA-C

Jordan Mast is a board-certified PA with a focus on general neurology. He attended Midwestern University and has over 12 years of experience practicing as a PA in neurology and headache medicine. Jordan has a special interest in providing education to other healthcare providers, patients, and industry professionals regarding best practices in management of neurological conditions and often serves as a speaker and consultant for medical education. He has also participated in several phase 2-4 clinical trials across a range of neurological conditions including Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, and stroke.